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R38 Respirology Common Medications Table 38. Common Medications for Respiratory Diseases (continued)
Toronto Notes 2019
Drug
ANTIBIOTICS – HOSPITAL ACQUIRED PNEUMONIA
Typical Adult Dose
1-2 g IV OD x 7-10 d
750 mg PO OD x 5 d 400 mg PO OD x 7 d (5 d for AECOPD)
4.5 g IV q6-8h x 7-10 d
1 g IV bid x 7-10 d
500 mg IV OD x 2 d, then 500 mg PO OD x 5 d 1,000 mg od or 500 mg PO bid x 7-10 d
0.5-30 μg/min IV 0.5 μg/kg/min IV 2-20 μg/kg/min IV
50-100 μg then 50-unlimited μg/h IV
1-3 mg/kg then 0.3-5 mg/ kg/h IV
Indications
Combine with fluoroquinolone or macrolide
Combine with 3rd gen cephalosporin
Suspect Pseudomonas
Suspect MRSA
Suspect Legionella
Acute hypotension Severe hypotension Inotropic support
Sedation and/or analgesia Sedation and/or analgesia
Side Effects
3rd gen Cephalosporin
Fluoroquinolone
Piperacillin/Tazobactam (Tazocin®)
Vancomycin (Vancocin®)
Macrolide
ICU MEDICATIONS
Pressors/Inotropes
Sedatives/Analgesia
ceftriaxone (Rocephin®)
levofloxacin moxifloxacin
Rash, diarrhea, eosinophilia, thrombocytosis, leukopenia, elevated transaminases
Rash, diarrhea, eosinophilia, thrombocytosis, leukopenia, elevated transaminases
CNS (confusion, convulsions, drowsiness), rash
Hematologic (abnormal platelet aggregation, prolonged PT, positive Coombs)
CNS (chills, drug fever), hematologic (eosinophilia), rash, red man syndrome, interstitial nephritis, renal failure, ototoxicity
CNS (chills, drug fever), hematologic (eosinophilia), rash, red man syndrome, interstitial nephritis, renal failure, ototoxicity
Angina, bradycardia, dyspnea, hyper/ hypotension, arrhythmias
See above
Bradycardia, respiratory depression, drowsiness, hypotension
Apnea, bradycardia, hypotension (good for ventilator sedation)
azithromycin clarithromycin
norepinephrine (Levophed®) phenylephrine
dobutamine
fentanyl (opioid class) propofol (anesthetic)
See Infectious Diseases, ID>> – for the management of pulmonary tuberculosis