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CP
Clinical Pharmacology
Felix Chan and Arman Zereshkian, chapter editors Arnav Agarwal and Priya Bapat, associate editors Danielle Jeong and Graham Mazereeuw, EBM editors Dr. David Juurlink, staff editor
Acronyms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
General Principles . . . . . . . . . . . . . . . . . . . . . . . . . 2
Drug Nomenclature
Phases of Clinical Drug Testing Drug Administration
Pharmacokinetics . . . . . . . . . . . . . . . . . . . . . . . . . 3
Absorption
Distribution
Metabolism (Biotransformation) Elimination
Pharmacokinetic Calculation
Pharmacodynamics . . . . . . . . . . . . . . . . . . . . . . . . 7
Dose-Response Relationship Effects of Drugs on Receptors Effectiveness and Safety Therapeutic Indices
Therapeutic Drug Monitoring . . . . . . . . . . . . . . . . 9 Adverse Drug Reactions . . . . . . . . . . . . . . . . . . . . 9
Approach to Suspected Adverse Drug Reactions
Variability in Drug Response . . . . . . . . . . . . . . . 10
Drug Interactions . . . . . . . . . . . . . . . . . . . . . . . . . 10
Autonomic Pharmacology . . . . . . . . . . . . . . . . . . 10
Parasympathetic Nervous System
Systemic Nervous System
Opioid Therapy and Chronic Non-Cancer Pain
Common Drug Endings . . . . . . . . . . . . . . . . . . . . 12 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
For more information on medical pharmacology, please refer to our new textbook, Pharmacology You See
Toronto Notes 2019 Clinical Pharmacology CP1