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H
Hematology
Hayeong Rho and Teja Voruganti, chapter editors
Helen Genis and Alexander Sapa, associate editors Melissa Allwood and Joshua Mehta, EBM editors
Dr. Martina Trinkaus and Dr. Richard Wells, staff editors
Acronyms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2
Basics of Hematology . . . . . . . . . . . . . . . . . . . . . .2
Complete Blood Count
Blood Film Interpretation
Bone Marrow Aspiration and Biopsy
Common Presenting Problems . . . . . . . . . . . . . . . 6
Anemia Erythrocytosis Thrombocytopenia Thrombocytosis Pancytopenia Neutrophilia Neutropenia Lymphocytosis Lymphopenia Eosinophilia Agranulocytosis Leukemoid Reaction
Approach to Lymphadenopathy . . . . . . . . . . . . . 12
Approach to Splenomegaly . . . . . . . . . . . . . . . . 13
Microcytic Anemia . . . . . . . . . . . . . . . . . . . . . . . . 13
Iron Metabolism
Iron Deficiency Anemia
Anemia of Chronic Inflammation Sideroblastic Anemia
Lead Poisoning
Normocytic Anemia . . . . . . . . . . . . . . . . . . . . . . . 17
Aplastic Anemia
Hemolytic Anemia . . . . . . . . . . . . . . . . . . . . . . . 18
Thalassemia
β-Thalassemia Minor (Thalassemia Trait) β-Thalassemia Major
β-Thalassemia Intermedia
α-Thalassemia
Sickle Cell Disease
Autoimmune Hemolytic Anemia Microangiopathic Hemolytic Anemia/ Thrombotic Microangiopathy
Hereditary Spherocytosis
Hereditary Elliptocytosis
Glucose-6-Phosphate Dehydrogenase Deficiency
Macrocytic Anemia . . . . . . . . . . . . . . . . . . . . . . . 23
Vitamin B12 Deficiency Folate Deficiency
Hemostasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
Stages of Hemostasis
Disorders of Primary Hemostasis . . . . . . . . . . . . 27
Immune Thrombocytopenia Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome
von Willebrand Disease
Toronto Notes 2019
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Landmark Hematology Trials . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60 Hematology H1
Disorders of Secondary Hemostasis . . . . . . .
Hemophilia A (Factor VIII Deficiency) Hemophilia B (Factor IX Deficiency) Factor XI Deficiency
Liver Disease
Vitamin K Deficiency
Disseminated Intravascular Coagulation
Hypercoagulable Disorders . . . . . . Venous Thromboembolism . . . . . .
Approach to Treatment of Venous Thromboembolism
Hematologic Malignancies and Related Disorders . . . . . . . . . . . . .
Myeloid Malignancies . . . . . . . . . .
Acute Myeloid Leukemia Myelodysplastic Syndromes
Myeloproliferative Neoplasms . . .
Chronic Myeloid Leukemia Polycythemia Vera Idiopathic Myelofibrosis Essential Thrombocythemia
Lymphoid Malignancies . . . . . . . .
Acute Lymphoblastic Leukemia
Lymphomas . . . . . . . . . . . . . . . . . .
Hodgkin Lymphoma Non-Hodgkin Lymphoma
Malignant Clonal Proliferations of Mature B-Cells . . . . . . . . . . . . . . . . Chronic Lymphocytic Leukemia Multiple Myeloma
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Monoclonal Gammopathy of Unknown Significance
Lymphoplasmacytic Lymphoma (Waldenstrom’s Macroglobulinemia)
Complications of Hematologic Malignancies
Hyperviscosity Syndrome Tumour Lysis Syndrome
Blood Products and Transfusions . . . . . . . . . .
Red Blood Cells
Platelets
Coagulation Factors
Acute Blood Transfusion Reactions Delayed Blood Transfusion Reactions
Common Medications . . . . . . . . . . . . . . . . . . .
Antiplatelet Therapy
Anticoagulant Therapy
Chemotherapeutic and Biologic Agents Used in Oncology
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