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RH
Rheumatology
Daniel Pau and Curtis Sobchak, chapter editors
Helen Genis and Alexander Sapa, associate editors
Melissa Allwood and Joshua Mehta, EBM editors
Dr. Simon Carette and Dr. Heather McDonald-Blumer, staff editors
Acronyms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
Anatomy of Joint Pathology . . . . . . . . . . . . . . . . . 2
Basics of Immunology . . . . . . . . . . . . . . . . . . . . . . 2
Immune Mechanisms of Disease Immunogenetics and Disease
Differential Diagnoses of Common
Presentations . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Synovial Fluid Analysis . . . . . . . . . . . . . . . . . . . . Septic Arthritis . . . . . . . . . . . . . . . . . . . . . . . . . . . Degenerative Arthritis: Osteoarthritis . . . . . . . . Seropositive Rheumatic Disease . . . . . . . . . . . .
Connective Tissue Disorders . . . . . . . . . . . . . . .
Rheumatoid Arthritis
Systemic Lupus Erythematosus Antiphospholipid Antibody Syndrome Scleroderma (i.e. Systemic Sclerosis) Idiopathic Inflammatory Myopathy Sjögren’s Syndrome
Mixed Connective Tissue Disease Overlap Syndrome
. 4 . 5 . 5 . 6 . 8
Vasculitides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Small Vessel Non-ANCA Associated Vasculitis Small Vessel ANCA-Associated Vasculitis Medium Vessel Vasculitis
Large Vessel Vasculitis
Seronegative Rheumatic Disease . . . . . . . . . . . . 21
Ankylosing Spondylitis Enteropathic Arthritis Psoriatic Arthritis Reactive Arthritis
Crystal-Induced Arthropathies . . . . . . . . . . . . . . 25
Gout
Pseudogout (Calcium Pyrophosphate Dihydrate Disease)
Non-Articular Rheumatism . . . . . . . . . . . . . . . . . 27
Polymyalgia Rheumatica Fibromyalgia
Common Medications . . . . . . . . . . . . . . . . . . . . . 29 Landmark Rheumatology Trials . . . . . . . . . . . . . 31 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32
Toronto Notes 2019
Rheumatology RH1